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Literature summary extracted from

  • Wang, Y.; Wu, S.; Zheng, S.; Wang, S.; Wali, A.; Ezhilarasan, R.; Sulman, E.P.; Koul, D.; Alfred Yung, W.K.
    APOBEC3G acts as a therapeutic target in mesenchymal gliomas by sensitizing cells to radiation-induced cell death (2017), Oncotarget, 8, 54285-54296 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.5.4.B9 medicine APOBEC3G mediated checkpoint activation through checkpoint kinase 2 (Chk2) is one of the critical regulatory mechanisms that underlies the preferential DNA damage checkpoint response and radioresistance of Glioma Initiating Cells. Thus, anti-APOBEC3G therapy may synergize with radiotherapy and other current treatments to overcome the therapeutic resistance of gliomas. APOBEC3G represents a potential molecular target for novel therapeutics that will improve the treatment outcome of glioma patients Homo sapiens
3.5.4.38 medicine APOBEC3G mediated checkpoint activation through checkpoint kinase 2 (Chk2) is one of the critical regulatory mechanisms that underlies the preferential DNA damage checkpoint response and radioresistance of Glioma Initiating Cells. Thus, anti-APOBEC3G therapy may synergize with radiotherapy and other current treatments to overcome the therapeutic resistance of gliomas. APOBEC3G represents a potential molecular target for novel therapeutics that will improve the treatment outcome of glioma patients Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.B9 Homo sapiens Q9HC16
-
-
3.5.4.38 Homo sapiens Q9HC16
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.B9 mesenchymal glioma stem cell APOBEC3G is preferentially expressed in mesenchymal gliomas Homo sapiens
-
3.5.4.38 mesenchymal glioma stem cell APOBEC3G is preferentially expressed in mesenchymal gliomas Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.5.4.B9 APOBEC3G
-
 Homo sapiens
3.5.4.38 APOBEC3G
-
 Homo sapiens